About PLN Genetic Heart Disease
For our heart to beat, calcium ions in the heart muscle cells are important. The phospholamban (PLN) protein plays an important role in the calcium balance of the heart muscle cells.
Heart disease is caused by a loss of cardiomyocytes (heart muscle cells), usually because of a heart attack or weakening of the cardiac muscle cells. Heart contractions and the ability to pump blood through our bodies depend on well orchestrated calcium movements in and out of the cell. The PLN (phospholamban) gene is a key regulator of the pump that controls calcium cycling. Scientific names for this PLN gene mutation are c.40_42del AGA and PLN.Arg14del. More about PLN Support Us
Latest news & blog articles
Save the date: PLN information day | November 7, 2020
A date is set for the PLN Information date 2020! When: Saturday November 7, 2020 Where: Amsterdam UMC, location AMC…
PLN carrier in the Corona crisis | Casper’s story
PLN carrier during the Corona crisis… how is that? What do encounter? And how do you deal with this? Casper…
Latest PLN Research results, developments & events
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PLN carrier in the Corona crisis | Casper’s story
PLN carrier during the Corona crisis… how is that? What do encounter? And how do you deal with this? Casper…
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Message of the passing of Professor Dimitrios Kremastinos
“The Clinical Co-Founder of Phospholamban R14del-Phospholamban Has Died from COVID-19 Complications The world of cardiology mourns the loss of…
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Questions about PLN research?
QUESTIONS ABOUT PLN RESEARCH? ASK YOUR QUESTIONS THIS WEEK TO THE UMC UTRECHT RESEARCH TEAM! Our researchers from UMC Utrecht…
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PLN Facts
“Almost all PLN patients are descendants from one person and can be almost completely linked to... a Dutch ancestor who lived some 575-825 years ago.”
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