About PLN Genetic Heart Disease
For our heart to beat, calcium ions in the heart muscle cells are important. The phospholamban (PLN) protein plays an important role in the calcium balance of the heart muscle cells.
Heart disease is caused by a loss of cardiomyocytes (heart muscle cells), usually because of a heart attack or weakening of the cardiac muscle cells. Heart contractions and the ability to pump blood through our bodies depend on well orchestrated calcium movements in and out of the cell. The PLN (phospholamban) gene is a key regulator of the pump that controls calcium cycling. Scientific names for this PLN gene mutation are c.40_42del AGA and PLN.Arg14del. More about PLN Support Us
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PLN Broadcast
Are you going to watch? October 20, 2020 | 6:15 pm | Dutch TV channel NPO1: an item about PLN…
PLN Foundation & internships
The PLN Foundation connects researchers worldwide, stimulates research, stimulates young talent and out-of-the-box ideas. We think it is great that…
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PLN Broadcast
Are you going to watch? October 20, 2020 | 6:15 pm | Dutch TV channel NPO1: an item about PLN…
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PhD!
Patricia Vanhooydonck-vd Hoogen will obtain her PhD at Utrecht University on September 14. For the past 4 years, as a…
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Cycling for PLN
An alternative Monstertocht: the “Elfstedentocht”! On September 12, 33 (!) cardiologists, doctors and general practitioners and others involved will cycle…
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PLN Facts
“Almost all PLN patients are descendants from one person and can be almost completely linked to... a Dutch ancestor who lived some 575-825 years ago.”
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