About PLN Genetic Heart Disease
For our heart to beat, calcium ions in the heart muscle cells are important. The phospholamban (PLN) protein plays an important role in the calcium balance of the heart muscle cells.
Heart disease is caused by a loss of cardiomyocytes (heart muscle cells), usually because of a heart attack or weakening of the cardiac muscle cells. Heart contractions and the ability to pump blood through our bodies depend on well orchestrated calcium movements in and out of the cell. The PLN (phospholamban) gene is a key regulator of the pump that controls calcium cycling. Scientific names for this PLN gene mutation are c.40_42del AGA and PLN.Arg14del. More about PLN Support Us
Latest news & blog articles
New PLN Monstertocht site
YES! Here it is: our new PLN Monstertocht website! We’re very proud and we’re going to make it a fantastic…
PLN Day in Murcia en Mula
More international cooperation: Pieter visits Mula, Spain, where PLN carriers live – a PLN carrier was born here back in…
Latest PLN Research results, developments & events
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New PLN Monstertocht site
YES! Here it is: our new PLN Monstertocht website! We’re very proud and we’re going to make it a fantastic…
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PLN Day in Murcia en Mula
More international cooperation: Pieter visits Mula, Spain, where PLN carriers live – a PLN carrier was born here back in…
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An award for Dr. Kranias
Dr. Litsa Kranias is rewarded with a prestigious reward: the Basic Research Prize: ” The American Heart Association awarded its Basic…
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PLN Facts
“Almost all PLN patients are descendants from one person and can be almost completely linked to... a Dutch ancestor who lived some 575-825 years ago.”
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