About PLN Genetic Heart Disease
For our heart to beat, calcium ions in the heart muscle cells are important. The phospholamban (PLN) protein plays an important role in the calcium balance of the heart muscle cells.
Heart disease is caused by a loss of cardiomyocytes (heart muscle cells), usually because of a heart attack or weakening of the cardiac muscle cells. Heart contractions and the ability to pump blood through our bodies depend on well orchestrated calcium movements in and out of the cell. The PLN (phospholamban) gene is a key regulator of the pump that controls calcium cycling. Scientific names for this PLN gene mutation are c.40_42del AGA and PLN.Arg14del. More about PLN Support Us
Latest news & blog articles
Update science | Zebra fish
The research groups of Jeroen Bakkers and Toon van Veen bring forward the first patient-specific model for the heart disease arrhythmogenic cardiomyopathy (ACM)….
Happy Holidays
Dear PLN family members and readers, Last year has flown by again. We started 2021 optimistic, full of plans. And…
Latest PLN Research results, developments & events
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Article in Netherlands Heart Journal
An article from Professor Doevendans, Professor Kuppatt, Professor Giacca and Pieter Glijnis in the Netherlands Heart Journal : artikel
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Update science | Zebra fish
The research groups of Jeroen Bakkers and Toon van Veen bring forward the first patient-specific model for the heart disease arrhythmogenic cardiomyopathy (ACM)….
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Update | Heart Tissue Bank
On the website of the Heart Tissue Bank a new and clear movie with a good explanation is posted. Watch…
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